Reactome MCP Server

augmented-nature/reactome-mcp-server

Model Context Protocol server for accessing Reactome pathway and systems biology data. Developed by Augmented Nature - Advancing AI for Scientific Discovery.

View on GitHub

Install

Client configuration

{
  "mcpServers": {
    "reactome-server": {
      "command": "node",
      "args": [
        "/path/to/reactome-server/build/index.js"
      ]
    }
  }
}

Author: @augmented-nature
Category: Research & Data, Education & Learning
Updated: Oct 6, 2026

About Reactome MCP Server

Model Context Protocol server for accessing Reactome pathway and systems biology data.

Developed by Augmented Nature - Advancing AI for Scientific Discovery

Features

Pathway Search - Search biological pathways by name, process, keywords
Pathway Details - Comprehensive pathway information and components
Gene-to-Pathways - Find pathways containing specific genes/proteins
Disease Pathways - Disease-associated biological mechanisms
Pathway Hierarchy - Parent/child relationships and pathway structure
Pathway Participants - All molecules participating in pathways
Biochemical Reactions - Detailed reaction information
Protein Interactions - Molecular interactions within pathways

Details on this page are taken from the project's README. Open README

Supported clients

Clients mentioned in this server's README:

View all

Claude Desktop

Desktop · Freemium · Proprietary

Anthropic's official Claude AI desktop application. Supports MCP servers to extend functionality.

WindowsMacOS

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