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Health & Wellness · Research & Data
Gtex MCP Server
augmented-nature/gtex-mcp-server
A comprehensive Model Context Protocol (MCP) server providing access to the GTEx (Genotype-Tissue Expression) Portal API. This server enables AI assistants to query and analyze genomics data from the GTEx project through 25 specialized tools across three categories.
Install
Client configuration
{
"mcpServers": {
"gtex-server": {
"command": "node",
"args": [
"/path/to/gtex-server/build/index.js"
]
}
}
}- Author
- @augmented-nature
- Category
- Health & Wellness, Research & Data
- License
- MIT
- Updated
- Oct 6, 2026
About Gtex MCP Server
The GTEx Portal contains gene expression and regulatory data from 54 non-diseased tissue sites across nearly 1000 individuals. This MCP server provides structured access to:
Tools (25)
get_gene_expression
Get gene expression data across tissues for specific genes
get_median_gene_expression
Get median gene expression levels across tissues
get_top_expressed_genes
Get top expressed genes in specific tissues
get_tissue_specific_genes
Get genes with tissue-specific expression patterns
get_clustered_expression
Get clustered gene expression data for visualization
calculate_expression_correlation
Calculate Pearson correlation between genes across tissues
get_differential_expression
Get differential gene expression between tissue groups
get_eqtl_genes
Get genes with eQTL associations for genomic regions
get_single_tissue_eqtls
Get single-tissue eQTL results for genes
calculate_dynamic_eqtl
Calculate dynamic eQTL effects across tissues
get_multi_tissue_eqtls
Get multi-tissue eQTL meta-analysis results
get_sqtl_results
Get splicing QTL (sQTL) results for genes
analyze_ld_structure
Analyze linkage disequilibrium structure around variants
search_genes
Search for genes by symbol, name, or description
get_gene_info
Get detailed information about specific genes
get_variants
Get genetic variants in genomic regions
get_tissue_info
Get information about GTEx tissues and sample counts
get_sample_info
Get GTEx sample metadata and demographics
get_subject_phenotypes
Get subject phenotype data and demographics
validate_gene_id
Validate and normalize gene identifiers
validate_variant_id
Validate variant identifiers and genomic coordinates
get_dataset_info
Get information about available GTEx datasets
search_transcripts
Search for gene transcripts and isoforms
get_gene_ontology
Get Gene Ontology annotations for genes
convert_coordinates
Convert between genomic coordinate systems (hg19/hg38)
Details on this page are taken from the project's README. Open README
Supported clients
Clients mentioned in this server's README:
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